Oxymetholone is well combined with certain injectable drugs, but do not combine it with the 17-alpha-alkylated steroids, since it will increase the hepatotoxicity. Anapolon often used for so-called "fast start" (anabolic effect begins to manifest itself very quickly), providing significant increase in strength and body weight in the very early stages of the cycle, while the other drugs in the stack gradually increase the concentration. The combination allows to achieve the best effect, due to the fact that oxymetholone reduces the concentration of sex hormone binding globulin, increasing the free fraction of other hormones, while it is synergist for a very large number of drugs. Anapolon has a low affinity for androgen receptors (bad contacts them) other high-androgenic hormones can provide a full effect through interaction with these receptors without competing with Anapolon. For muscle mass gain, Anapolon is combined with testosterone, Boldenone, Primobolan, but not with Nandrolone and Trenbolone, because it can lead to a more pronounced progestin effect.
The use of anabolic steroids will suppress natural testosterone. The rate of suppression is dependent on the steroid in question, but in the case of Oxymetholone it is enough to warrant the use of exogenous testosterone. This will actually hold true with most anabolic steroids. Those who supplement with Anadrol and forgo exogenous testosterone therapy will fall into a low testosterone condition. Not only is this a condition that comes with numerous bothersome symptoms, it is an extremely unhealthy state. The form of testosterone you choose when using Anadrol is of no consequence, however, you should ensure you are applying enough to provide what the body needs.
Once the use of Anadrol and all anabolic steroids has come to an end and all the exogenous hormones have cleared your system natural testosterone production will begin again. This is assuming there was no prior existing low level state. It also assumes no damage was done to the HPTA during supplementation due to improper practices. While natural testosterone production will begin again on its own, it will not be fast. It is generally recommended that the individual begin a Post Cycle Therapy (PCT) treatment plan following anabolic steroid use . This will encourage natural testosterone production and speed the healing process up. It will not automatically return you to your previous natural high level on its own; that will take some time. However, it will ensure you have enough testosterone in your body to function properly while your levels continue to naturally rise.