Oxandrolone is most certainly a hepatotoxic steroid. It does not carry the strongest level of hepatotoxicity among anabolic steroids, but it is stronger than most. This is due to it being a C17-aa anabolic steroid. All C17-aa steroids are hepatic, but the level of toxicity varies greatly between them. Due to this steroid’s strong hepatotoxicity, this is why total use must be limited (see administration section).
Due to use, those who supplement with Anadrol will find their liver enzyme values increase. An increase in values is not a sign of damage but rather a sign of stress that can lead to damage if responsible practices are not followed and the stress is allowed to remain. Proper dosing and duration of use protocols are imperative when it comes to this steroid. Further, it is important the individual avoids excess alcohol consumption when supplementing with this steroid due to the liver stress such consumption will cause. In fact, most will find avoiding all alcohol to be best during use. If this is a problem and you are supplementing for the purpose of performance enhancement remember there is nothing on earth that is as anti-performance as alcohol. Those who supplement are also encouraged to limit their use of Over the Counter (OTC) medications. Many OTC medications carry strong hepatic natures, and the added stress can be extensive when coupled with Anadrol. Use should be limited to when only absolutely needed. If these rules can be followed, once use is discontinued liver enzyme values will return to normal and no damage will be done. As a final note, Anadrol should not be used if the liver is unhealthy.
With the structural (c17-AA) alteration, the tablets will place a higher level of stress on the liver than the injectable. During longer or higher dosed cycles, liver values should therefore be watched closely through regular blood work. Such stress would of course be amplified when adding other c17-AA oral compounds to a cycle of stanozolol. When using such combinations, cautious users would make every effort to limit the length of the cycle not to be longer than a maximum of 6-8 weeks. It is also of note that stanozolol has been linked to strong adverse changes in the cholesterol levels. This side effect is common with anabolic steroid therapy, and obviously can become a health concern as the dose/duration of intake increase above normal. The oral version should have a greater impact on cholesterol values than the injectable due to the method of administration, and may therefore be the worse choice of the two for those concerned of this side effect. The oral use of stanozolol can also have a profound impact on levels of SHBG (sex hormone-binding globulin). This is characteristic of all anabolic/androgenic steroids, however its potency and form of administration makes oral stanozolol particularly noteworthy in this regard. Since plasma binding proteins such as SHBG act to temporarily constrain steroid hormones from exerting activity, this effect would provide a greater percentage of free (unbound) steroid hormone in the body. This may amount to an effective mechanism in which stanozolol could increase the potency of a concurrently used steroid. Proviron has an extremely high affinity for SHBG. This affinity may cause Proviron to displace other weaker substrates for SHBG, another mechanism in which the free hormone level may be increased. Adding stanozolol and Proviron to a testosterone cycle may therefore prove very useful, markedly enhancing the free state of this potent muscle building androgen.