Methenolone acetate liver

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Norgestimate, also known as 17α-ethynyl-18-methyl-19-nortestosterone 3-oxime 17β-acetate or as 17α-ethynyl-18-methylestr-4-en-17β-ol-3-one 3-oxime 17β-acetate , is a synthetic estrane steroid and a derivative of testosterone . [7] [8] It is more specifically a derivative of norethisterone (17α-ethynyl-19-nortestosterone) and is a member of the gonane (18-methylestrane) subgroup of the 19-nortestosterone family of progestins. [9] Norgestimate is the C3 oxime and C17β acetate ester of levonorgestrel and is also known as levonorgestrel acetate oxime . [10] A related compound is norethisterone acetate oxime (norethisterone-3-oxime 17β-acetate).

The risk of hepatotoxicity and death associated with CPA treatment is reportedly the reason that CPA has not been approved by the FDA for use in the United States. [50] Patients being treated with high-dose CPA should be closely monitored with liver function tests . [51] The risk is dose-dependent, and the low doses of CPA used in birth control pills (2 mg) have been said to represent a non-significant risk. [52] However, a German woman who had been taking Diane-35 (containing 2 mg/day CPA) for contraception for 14 years died of liver cancer, and this led to a safety review by drug regulators and the eventual restriction of CPA throughout Europe for the indication of acne treatment in women. [46]

Methenolone acetate liver

methenolone acetate liver

Norgestimate, also known as 17α-ethynyl-18-methyl-19-nortestosterone 3-oxime 17β-acetate or as 17α-ethynyl-18-methylestr-4-en-17β-ol-3-one 3-oxime 17β-acetate , is a synthetic estrane steroid and a derivative of testosterone . [7] [8] It is more specifically a derivative of norethisterone (17α-ethynyl-19-nortestosterone) and is a member of the gonane (18-methylestrane) subgroup of the 19-nortestosterone family of progestins. [9] Norgestimate is the C3 oxime and C17β acetate ester of levonorgestrel and is also known as levonorgestrel acetate oxime . [10] A related compound is norethisterone acetate oxime (norethisterone-3-oxime 17β-acetate).

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