Methenolone profile

Tibolone has tissue -selective estrogenic effects, with desirable effects in bone , the brain , and the vagina , and lack of undesirable action in the endometrium and breasts . [16] Its tissue selectivity is the result of metabolism , enzyme modulation (., of estrogen sulfatase and estrogen sulfotransferase ), and receptor modulation that vary in different target tissues, and differs mechanistically from that of selective estrogen receptor modulators (SERMs) such as tamoxifen , which produce their tissue-selectivity via means of modulation of the ER. [15] [16] As such, to distinguish it from SERMs, tibolone has been described as a "selective tissue estrogenic activity regulator" (STEAR), [16] and also as a "selective estrogen enzyme modulator" (SEEM). [17]

Most of my recommendations for considering yourself an advanced steroid user are self-explanatory. Basically, my worry here is that no matter how many cycles you´ve done, if you´re losing half of your gains from each cycle, then you have a lot of work to do to figure out what you´re doing wrong after your cycles end. There´s really no way around that fact & if you´re not keeping half of your gains, then something is going wrong when you end your cycles. Before you jump into an advanced cycle, with multiple compounds and drugs, you need to get your post cycle in order. If you´re losing more than half your gains from every cycle… then something isn´t in check. You aren´t an advanced steroid user you´ve just used a lot of them. But, if you keep most of your gains from each cycle, and meet the other 3 criteria for being advanced, then this cycle is for you!

Methenolone profile

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