Anabolic steroids are synthetic derivatives of testosterone . Certain clinical effects and adverse reactions demonstrate the androgenic properties of this class of drugs. Complete dissociation of anabolic and androgenic effects has not been achieved. The actions of anabolic steroids are therefore similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testes .
All of the 17 alpha alkylated androgens carry warnings about hepatotoxicity, peliosis, and liver cell tumors. While the tumors are mostly benign, fatal malignant tumors have been reported. Withdrawal of the drug results in complete disappearance of the peliosis and regression or cessation of progression of benign tumors. It would appear that these complications occur to a lesser extent with oxandrolone than with other drugs in the class which are almost completely metabolized in the liver. In contrast, one third of oxandrolone is excreted unchanged in the urine and the rest undergoes considerably less metabolic transformation in the liver. (15) Patients on long-term androgen therapy should receive the lowest dose possible and should have annual liver ultrasonography. Androgens are contraindicated in patients with pre-existing cardiac, renal, or hepatic disease. In children, careful monitoring is required because androgen therapy may accelerate bone maturation without producing compensatory gain in linear growth. The presence of this adverse effect results in compromised adult height. Women should be observed for signs of virilization (deepening of the voice, hirsutism, acne, and clitoromegaly). Discontinuation of drug therapy at the time of evidence of mild virilism is necessary to prevent irreversible virilization.
Anavar is no longer manufactured by legitimate pharmacies, so no matter what anyone tells you about this or that brand being “pharm grade”, all anavar is being manufactured by underground labs and the typical dosage is 10 mgs a pill – far greater than the original intended dosing. Then again, how can you ever be sure what the exact dosage is? Different underground labs may use their own title for the drug, but most simply call it, not by its chemical name “Oxandrolone”, but by the original brand name of “Anavar.”