These effects were mimicked in a rat study where Caralluma fimbriata was administrated at 25, 50, and 100mg/kg bodyweight for 90 days in conjunction with an ad libitum (no dietary controls) diet caused dose-dependent reductions in food intake and body weight, with the group fed both Caralluma and an obesogenic diet undereating the control balanced diet (and obesogenic diet without Caralluma eating more than control).  The effects in this study appeared to manifest after 45 days, suggesting that the benefits are not acute (human study was not designed to answer the question as to what the time-related response was). 
Use of QVAR with a spacer device in children less than 5 years of age is not recommended. In vitro dose characterization studies were performed with QVAR 40 mcg/actuation with the OptiChamber and AeroChamber Plus ® spacer utilizing inspiratory flows representative of children under 5 years old. These studies indicated that the amount of medication delivered through the spacing device decreased rapidly with increasing wait times of 5 to 10 seconds as shown in Table 2. If QVAR is used with a spacer device, it is important to inhale immediately.
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